Players purchase card packs, which give the player random items, with Virtual Currency (VC). Players collect cards that unlock players, playbooks, and other items that can be used in their team or sold. Players build their own custom team, selecting the players, jerseys, logos, coach, court, and other basketball related things, and play with their team in basketball tournament-style competitions against other players' teams. NBA 2K19, for the seventh time in the series, features MyTeam mode, a mode based around the idea of building the ultimate basketball team, and maintaining a virtual trading card collection. 'The Way Back' also features authentic CBA commentary in Mandarin Chinese, a first of the series. The career mode is titled 'The Way Back' and stars Anthony Mackie, Aldis Hodge, Haley Joel Osment, Ginger Gonzaga, Rob Huebel, Mo McRae, Ricky Whittle and Michael Rapaport. It received generally favorable reviews from critics, who praised the gameplay and some calling it the best installment of the series, while its emphasis on microtransactions was criticized. NBA 2K19 was released on Septemfor Microsoft Windows, Nintendo Switch, PlayStation 4, and Xbox One.

Antetokounmpo and James grace the cover in North America, while Australia native Ben Simmons of the Philadelphia 76ers is featured on the cover in Australia and New Zealand.

Giannis Antetokounmpo of the Milwaukee Bucks is the cover athlete for the standard edition, while LeBron James (who was also the cover athlete of NBA 2K14) of the Los Angeles Lakers is the cover athlete for the 20th Anniversary Edition. It is the 20th installment in the NBA 2K franchise, the successor to NBA 2K18, and the predecessor to NBA 2K20. NBA 2K19 is a 2018 basketball simulation video game developed by Visual Concepts and published by 2K, based on the National Basketball Association (NBA).

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